What is a Depolymerizing agent?
Depolymerization (or depolymerisation) is the process of converting a polymer into a monomer or a mixture of monomers.
What does microtubule depolymerizing agent do?
Indanocine, a potent microtubule depolymerizing agent, is highly active against multidrug-resistant (MDR) cancer cells without affecting normal cells. It is known to disrupt microtubule dynamics in cells and induce apoptotic cell death.
What is tubulin binding agent?
Epothilones. Epothilones are a new class of agent that, like paclitaxel, disrupt microtubule dynamics by binding to the β-tubulin subunit of α–β-tubulin and stabilize microtubules, inducing mitotic arrest and apoptosis. Epothilones and taxanes share overlapping but not identical binding sites on β-tubulin10.
What is tubulin responsible for?
The tubulin proteins α- and β polymerize into long chains or filaments that form microtubules, an essential element of the eukaryotic cytoskeleton. These microtubules play a crucial role in cell support and cell movement, making tubulin imperative to normal cell function.
What is the process of depolymerization?
Depolymerization is the process or act of breaking down a polymer into its monomeric components. It is the opposite of polymerization, which is the act or process where monomers join together to form a polymer.
What is meant by depolymerization?
Depolymerization is a process that converts the polymers (macromolecules) into component monomers (smaller molecules).
What is meant by tubulin?
Tubulins are the building blocks of microtubules (narrow, hollow tubes inside a cell), which are involved in cell division and cell movement. …
What is an example of depolymerization?
Example of a biological depolymerization is the digestion of food. Macromolecules in food such as carbohydrates and proteins are degraded into simpler forms. The process is often facilitated by the catalytic action of various enzymes. For example, the amylase in the saliva degrades polysaccharide starch into maltose.