Why primaquine is contraindicated in G6PD?
Primaquine should not be administered to anyone with G6PD deficiency because a severe reaction can occur, resulting in hemolytic anemia.
What is the mechanism of action of primaquine?
Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria.
How is chloroquine synthesized?
3), is made by reacting 4,7-dichloroquinoline (37.1. 1.1) with 4-diethylamino-1-methylbutylamine (37.1. 1.2) at 180 °C [1–3]. In order to realize the synthesis, the necessary 4,7-dichloroquinoline (37.1.
Is primaquine a quinoline?
Antimalarial drugs are also classified based on their structures into groups such as 4-aminoquinolines, like chloroquine and amodiaquine (10); 8-aminoquinolines such as primaquine; 4-quinolinemethanols, e.g., mefloquine; quinoline-containing cinchona alkaloids, e.g., quinine and quinidine (11); hydroxynaphthoquinones.
Is chloroquine and primaquine same?
Chloroquine is a highly effective schizontocide, while primaquine has weaker asexual-stage activity (3) but is the only generally available drug with hypnozoitocidal properties, i.e., it kills dormant liver stage parasites and prevents relapse (radical cure) (1).
What is primaquine phosphate used for?
Primaquine is used alone or with another medication to treat malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent the disease from coming back in people that are infected with malaria. Primaquine is in a class of medications called antimalarials.
What is the generic name of chloroquine?
ARALEN, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. ARALEN is an antimalarial and amebicidal drug.
What are the side effects of primaquine?
Side Effects
- Back, leg, or stomach pains.
- black, tarry stools.
- bluish-colored lips, fingernails, or palms.
- chest pain.
- difficulty breathing.
- dizziness, faintness, or lightheadedness.
- fast, slow, pounding, or irregular heartbeat.
- general body swelling.
Is mefloquine a 4 Aminoquinoline?
Mefloquine is a 4-aminoquinoline compound and may have a similar mode of action to that of chloroquine. Resistance to mefloquine is less common but increasing; it arises from increased activity of the same efflux transporter.