What are CYP1A2 inducers?
CYP1A2 Inducers Barbiturates. Cruciferous vegetables. Grilled meat. Carbamazepine (eg, Tegretol) Primidone.
How do you increase CYP1A2 enzymes?
Vegetables such as cabbages, cauliflower and broccoli are known to increase levels of CYP1A2. Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme.
Is caffeine a CYP1A2 inhibitor?
CYP1A2 is involved in the metabolism of, e.g., agomelatin, caffeine, clozapine, duloxetine, propranolol, tizanidine, and zolmitriptan, as well as some endogenous compounds, such as melatonin and estradiol.
What affects CYP1A2?
Several factors in human exposures have been associated with the modulation of CYP1A2 activity, including smoking and various dietary agents. In tissue samples from patients of known smoking status, CYP1A2 content was 3.5‐fold higher in smokers than in nonsmokers (Sesardic et al. 1988).
What is a CYP1A2 inhibitor?
Like many of other CYPs, CYP1A2 is subject to induction and inhibition by a number of compounds. In particular, several therapeutic drugs including antofloxacin, carbamazepine, dihydralazine, furafylline, isoniazid, rofecoxib, clorgyline, thiabendazole, and zileuton are mechanism-based inhibitors of CYP1A2.
What does CYP1A2 metabolize?
CYP1A2 metabolizes endogenous compounds such as retinols, melatonin, steroids, uroporphyrinogen and arachidonic acids and plays a major role in procarcinogen activation and DDIs, due to induction and inhibition by several therapeutic drugs.
How are inducers and inhibitors of CYP1A2 classified?
Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency , such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or more than 80% decrease in clearance thereof.
How does the cyp1a2-163a / a genotype influence carbamazepine pharmacokinetics?
CYP1A2 -163A/A genotype influence carbamazepine pharmacokinetics. niclosamide was subjected to efficient metabolic reactions hydroxylation and glucuronidation, wherein CYP1A2 and UGT1A1 were the main contributing enzymes, respectively. Pregnane X receptor likely regulates CYP1A2 expression in 3D spheroids of liver cancer cells.
Is there any evidence for CYP1A2 genotype based dosing?
Furthermore, earlier studies including only single variants might have missed more complex haplotypes including several variants. Taken together, the current available evidence does not support CYP1A2 genotype-based dosing for any drug. E.H.J. Krekels,
Why is CYP1A2 lower in South Asians?
Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme. Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency, such as: