What is AZFc?

What is AZFc?

Azoospermic factor c (AZFc) deletions are a common molecular cause of spermatogenic failure with a frequency of about 10% in men with non-obstructive azoospermia or severe oligozoospermia (Vogt et al., 1996; Kuroda-Kawaguchi et al., 2001).

What is Y chromosome deletion?

Y chromosome infertility is caused by deletions of genes in the AZF regions. These deletions remove several genes, or in rare cases, a single gene. Loss of this genetic material likely prevents the production of one or more proteins needed for normal sperm cell development.

Why is intracytoplasmic sperm injection done?

ICSI is used to treat severe male infertility, as when little or no sperm are ejaculated in the semen. Immature sperm collected from the testicles usually can’t move about and are more likely to fertilize an egg through ICSI. ICSI can be used even if a couple’s infertility is not related to a problem with sperm.

How long can Y chromosome sperm survive?

You need to know that the maximum amount of time sperm can live in a woman’s reproductive system is 5 days. Some sperm will live for a shorter time, depending on the conditions in the vagina, fallopian tubes and uterus. (Such as the consistency of cervical mucus.)

What is the lifespan of Y sperm?

For a boy, sperm with the Y chromosome should be deposited as close as possible to the egg because the Y chromosome has a short lifespan and it will not live longer than 24 hours, compared with the sperm with the Y chromosome which will live in a woman’s body for up to 72 hours.