What is the role of bioinformatics in identifying target genes?
Genomics and proteomics technologies have created a paradigm shift in the drug discovery process, with bioinformatics having a key role in the exploitation of genomic, transcriptomic, and proteomic data to gain insights into the molecular mechanisms that underlie disease and to identify potential drug targets.
How is bioinformatics useful in drug discovery?
Bioinformatic analysis can not only accelerate drug target identification and drug candidate screening and refinement, but also facilitate characterization of side effects and predict drug resistance.
What is drug designing in bioinformatics?
Drug design or rational drug design, is the discover process of finding new medications based on the knowledge of a biological target.
What is target bioinformatics?
2.1 Tools and Resources for Drug Target Identification Drug target identification involves acquiring a molecular level understanding of a specific disease state and includes analysis of gene sequences, protein structures, protein-protein interactions, and metabolic pathways.
What is the study of how genes affect a person’s response to drugs?
Pharmacogenomics (also known as pharmacogenetics) is the study of how our genes affect the way we react and respond to medications. The word “pharmacogenomics” comes from the words pharmacology (the study of the uses and effects of medications) and genomics (the study of genes and their functions).
What is the role of bioinformatics in Covid 19?
In the face of the current COVID-19 pandemic, the comprehensive application of bioinformatics techniques on relevant genome sequences deposited in online repositories could tremendously aid the search for a potent vaccine and drug that will combat the spread of the virus.
What are the methods of drug discovery?
For drug discovery, two different complementary approaches can be applied: classical pharmacology, also known as phenotypic drug discovery, which is the historical basis of drug discovery, and reverse pharmacology, also designated target-based drug discovery.
What is the starting point for drug discovery?
Many secondary metabolites produced by plants have potential therapeutic medicinal properties. These secondary metabolites contain, bind to, and modify the function of proteins (receptors, enzymes, etc.). Consequently, plant derived natural products have often been used as the starting point for drug discovery.
What is the difference between core and pan genome?
The core genome represents the basic genes necessary for information transmittal and production of gene products. The pan-genome includes all of the genes that are different in the genomic comparison. These are the genes that make each individual species or strain unique.
What is drug discovery?
The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.