What is cardiomyocyte apoptosis?
Since cardiomyocyte apoptosis is a highly regulated process, pharmacological intervention of apoptosis pathways may represent a promising therapeutic strategy for a number of cardiovascular diseases and disorders including myocardial infarction, ischemia/reperfusion injury, chemotherapy cardiotoxicity, and end-stage …
What is myocardial cell death?
Death of myocardial cells such as cardiomyocytes compromises contractility of the heart muscle, which in turn instigates adverse remodeling that ultimately leads to cardiac dysfunction and subsequent heart failure.
What is pathological cell death?
More than half of the initially-formed neurons are deleted in certain brain regions during normal development. This process, whereby cells are discretely removed without interfering with the further development of remaining cells, is called programmed cell death (PCD).
What is a cardiomyocyte cell?
Cardiomyocytes are the cells responsible for generating contractile force in the intact heart. • Specialized cardiomyocytes form the cardiac conduction system, responsible for control of rhythmic beating of the heart.
Is cardiac cell death reversible?
MI and HF are associated with significant loss of cardiac myocytes, a process that has been thought to be irreversible.
Is myocardial cell death reversible?
of myocardial function, but it is considered acute and completely reversible. myocardial function of variable duration, primarily caused by impaired oxygen delivery through an occluded vessel, and recov- ery of function occurs on reflow to the ischemic region.
What causes cell death during a myocardial infarction?
During myocardial infarction, cardiac myocytes in the ischemic zone die by both apoptosis and necrosis. Surprising, the magnitudes of each form of cell death remain unclear.
What happens to cells after death?
After death, the cells are depleted of their energy source and the protein filaments become locked in place. This causes the muscles to become rigid and locks the joints. During these early stages, the cadaveric ecosystem consists mostly of the bacteria that live in and on the living human body.
What is a heart cell called?
The human body contains three different kinds of muscle tissue: skeletal, smooth, and cardiac. Only cardiac muscle tissue, comprising cells called myocytes, is present in the heart.