How do I read my fish test results?

How do I read my fish test results?

How your doctor interprets this test is as follows:

  1. A result of 0 is negative.
  2. A result of 1+ is also negative.
  3. A result of 2+ is considered equivocal (uncertain).
  4. A result of 3+ is positive.

What is FISH report in cancer?

Fluorescence in situ hybridization (FISH) is a test that “maps” the genetic material in human cells, including specific genes or portions of genes. Because a FISH test can detect genetic abnormalities associated with cancer, it’s useful for diagnosing some types of the disease.

How FISH can be used to confirm HER2 gene amplification in breast cancer cells?

FISH testing is done on breast cancer tissue removed during biopsy to see if the cells have extra copies of the HER2 gene. The more copies of the HER2 gene that are present, the more HER2 receptors the cells have. These HER2 receptors receive signals that stimulate the growth of breast cancer cells.

What is FISH ratio?

The HER2/CEP17 fluorescence in situ hybridization (FISH) ratio was associated with a pathologic complete response (pCR) with the use of dual anti-HER2 therapy in patients with HER2-positive breast cancer without the use of chemotherapy, suggesting that FISH may be a predictive biomarker of anti-HER2 response, according …

What does HER2 FISH positive mean?

FISH testing usually returns one of two results: positive or negative. Positive means your breast cancer cells make too much HER2 and your doctor should treat you with drugs that target that protein. Negative means the protein isn’t involved in the growth of your tumor.

How do I read my HER2 FISH test results?

The interpretation for HER2 FISH testing (HER2-to-CEP17 ratio and gene copy number) is as follows:

  1. Positive HER2 amplification: FISH ratio higher than 2.2 or HER2 gene copy greater than 6.0.
  2. Equivocal HER2 amplification: FISH ratio of 1.8-2.2 or HER2 gene copy of 4.0-6.0.

Is it better to have HER2-positive or negative?

Is HER2-positive breast cancer good or bad? HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast.