What is Integrilin made from?

What is Integrilin made from?

Eptifibatide is a cyclic heptapeptide derived from a disintegrin protein (P22827) found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life.

Is Integrilin a blood thinner?

BRAND NAME(S): Integrilin. USES: Eptifibatide is a type of “blood thinner” used to prevent blood clots that can cause a heart attack or other serious blood flow problems.

How is Integrilin administered?

Withdraw the bolus dose(s) of INTEGRILIN from the 10-mL vial into a syringe. Administer the bolus dose(s) by IV push. Immediately following the bolus dose administration, initiate a continuous infusion of INTEGRILIN. When using an intravenous infusion pump, administer INTEGRILIN undiluted directly from the 100-mL vial.

What is Integrilin used for?

Overview. Eptifibatide injection is used to prevent blood clots from forming in the arteries of the heart after certain types of chest pain and heart attacks. It may also be used in patients who are having certain heart and blood vessel procedures, such as coronary angioplasty.

Does eptifibatide raise blood pressure?

Common side effects of Integrilin injection include: bleeding. low blood pressure.

How do you reverse abciximab?

Currently, there is no available reversal agent. Therefore, platelet transfusion is recommended for reversing the effect of abciximab. Eptifibatide (Integrilin) is approved for use in patients with acute coronary syndrome, including patients scheduled for PCI.

How fast do you push Integrilin?

INTEGRILIN should be given concomitantly with heparin to achieve a target ACT of 200 to 300 seconds. Administer 60-units/kg bolus initially in patients not treated with heparin within 6 hours prior to PCI.

What class of drug is eptifibatide?

Eptifibatide is a glycoprotein IIb/IIIa class platelet inhibitor drug used to reduce ischemic cardiac events in specific patient populations.

How do I reverse eptifibatide?

There is no available reversible agent for eptifibatide. Therefore, platelet transfusion is the option to reverse the effect of the drug.

What is dalteparin sodium prescribed for?

Dalteparin is used in combination with aspirin to prevent serious or life-threatening complications from angina (chest pain) and heart attacks.

Why was ReoPro discontinued?

Supplies of abciximab (ReoPro; Janssen Pharmaceuticals) are running low or have dried up altogether, following a manufacturing snafu affecting stocks of the glycoprotein IIb/IIIa Inhibitor around the globe.