What is the difference between endochondral and intramembranous ossification?
In intramembranous ossification, bone develops directly from sheets of mesenchymal connective tissue. In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length.
What is the endochondral ossification process?
Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. Most of the bones of the skeleton are formed in this manner. These bones are called endochondral bones. In this process, the future bones are first formed as hyaline cartilage models. This forms a primary ossification center.
What are the 3 stages of bone development?
The process of bone formation is called osteogenesis or ossification. After progenitor cells form osteoblastic lines, they proceed with three stages of development of cell differentiation, called proliferation, maturation of matrix, and mineralization.
What is the purpose of intramembranous ossification?
Intramembranous ossification is the process of bone development from fibrous membranes. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles. Ossification begins as mesenchymal cells form a template of the future bone.
Does ossification ever stop?
Ossification of long bones proceeds until only a thin strip of cartilage remains at either end; this cartilage, called the epiphyseal plate, persists until the bone reaches its full adult length and is then replaced with bone.
What are the 6 steps of endochondral ossification?
Terms in this set (6)
- Cartilage enlarges; Chondrocytes die.
- blood vessels grow into perichondrium; cells convert to osteoblasts; shaft becomes covered with superficial bone.
- more blood supply and osteoblasts; produces spongy bone; formation spreads on shaft.
- Osteoclasts create medullary cavity; appositional growth.
Why is endochondral ossification important?
The coordinated process of endochondral ossification is essential to the development and growth of long bones of the body, but also regulates fracture repair, as is discussed in Section 2.210.
How do I know if my child’s long bone is growing?
Pediatric orthopedic surgeons can estimate when growth will be completed by determining a child’s “bone age.” They do this by taking an x-ray of the left hand and wrist to see which growth plates are still open. The bone age may be different from the child’s actual age.