What is the difference between dominant and codominant marker?
Codominant markers indicate differences in size whereas dominant markers are either present or absent. Codominant markers may have many different alleles whereas a dominant marker only has two alleles.
Is there a genetic marker for heart disease?
A mutated gene, SLCO1B1, was found to be associated with high levels of blood fatty acid, which is a strong predictor for the development of future heart failure and the mutation itself has a direct effect on heart failure risk.
Which of the following co markers is dominant?
RFLP, SSR, STS, STMS etc are co-dominant markers and RAPD, ISSR, AFLP, DAF etc are dominant markers.
Is heart disease a dominant or recessive trait?
Most genetic heart conditions are inherited in an autosomal dominant pattern. Autosomal means that both men and women are equally affected. Dominant means that although there are two copies of each gene, a mutation in just one copy is enough to cause disease.
Why RFLP is a codominant marker?
RFLPs and other molecular markers are typically inherited in a co-dominant mode: both alleles are expressed as a molecular phenotype. The phenotypes are recognized as sets of bands of particular size in electrophoresis gels. Molecular genotypes may be detected by a variety of methods.
What is a counter selectable marker?
Negative or counterselectable markers are selectable markers that eliminate or inhibit growth of the host organism upon selection. An example would be thymidine kinase, which makes the host sensitive to ganciclovir selection.
What is a family history of heart disease?
A family history of heart disease is generally defined by having a first-degree male relative (i.e., father or brother) who had a heart attack by age 55, or a first-degree female relative (i.e., mother or sister) by age 65. Just as important, consider lifestyle changes that improve your heart health.
Is RFLP a dominant marker?
RFLP, as a molecular marker, is specific to a single clone/restriction enzyme combination. Most RFLP markers are co-dominant (both alleles in heterozygous sample will be detected) and highly locus-specific.
How much of a role does genetics play in heart disease?
Genetics can influence the risk for heart disease in many ways. Genes control every aspect of the cardiovascular system, from the strength of the blood vessels to the way cells in the heart communicate. A genetic variation (mutation) in a single gene can affect the likelihood of developing heart disease.
What is the most rare heart disease?
Restrictive cardiomyopathy is the rarest form of heart-muscle disease. Here’s an overview.
What are the advantages of RFLP?
The main advantages of RFLPs include: 1) high reliability, because it is generated from specific sites via known restriction enzymes and the results are constant over time and location. 2) Co-dominance, which means investigators are able to distinguish heterozygotes from homozygotes.