What antiemetics prolong QT?
Chlorpromazine (THORAZINE) and promethazine (PHENERGAN) may prolong the QT interval.
Which antiemetic does not cause QT prolongation?
Both ondansetron and granisetron prolong the QT interval when administered intravenously at doses over 8 mg and 10 micrograms/kg respectively. However, there have been no reports of QT prolongation following oral administration. Palonosetron and tropisetron are not associated with QT prolongation.
Does prochlorperazine prolong QTc?
Prochlorperazine may increase the risk of QT interval prolongation. Best to avoid use with other potentially QT-prolonging medications.
When should QT prolongation be considered in antiemetic use?
QTc prolongation from routine doses of 4–8 mg of ondansetron is minimal and is unlikely to be clinically significant or cause a dangerous arrhythmia. A patient who receives a single dose of an antiemetic does not require routine screening electrolytes or an electrocardiogram (ECG).
Does Benadryl prolong QT interval?
The histamine H1 receptor antagonist diphenhydramine inhibits the fast sodium channels and at higher concentrations inhibits the repolarizing potassium channels which leads to prolongation of the action potential and the QT interval.
Which drugs prolong QT the most?
Drugs that cause QTc prolongation A long QT interval is most frequently seen with class I and class III antiarrhythmic drugs. Other classes of drugs that cause QTc prolongation include antihistamines, antidepressants, antibiotics, antifungal drugs and antipsychotics (Table 2).
Does Trimethobenzamide prolong QTc?
Based on the results of this retrospective analysis, trimethobenzamide was shown to be effective in reducing N/V symptoms while not prolonging the QTc interval further.
Does Benadryl cause QT prolongation?
Does Benadryl have any cardiac side effects?
Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.