What is TFA chemical?
Uses. TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride, trifluoroperacetic acid, and 2,2,2-trifluoroethanol. TFA is a versatile solvent for NMR spectroscopy (for materials stable in acid). It is also used as a calibrant in mass spectrometry.
Why is TFA a strong acid?
TFA is a stronger acid than acetic acid, having an acid ionisation constant, Ka, that is approximately 34,000 times higher, as the highly electronegative fluorine atoms and consequent electron-withdrawing nature of the trifluoromethyl group weakens the oxygen-hydrogen bond (allowing for greater acidity) and stabilises …
Is TFA an organic acid?
Trifluoroacetic acid 1 (TFA, d 1.480) is the simplest perfluoroorganic acid available, characterized by its strong acidity (pKa 0.23 at 25 °C in H2O), high dielectric constant (ɛ = 42.1 at 25 °C), miscibility with water and most organic solvents and relativity low boiling point (71.8 °C) [1(a–c)].
Is CF3COO an acid or base?
The conjugate base of CF3COOH is CF3COO-, but the conjugate of the other acid is CH3OH (methanol, and NOT an anion).
How do you remove TFA from a compound?
To remove traces of TFA you can use exsiccator with KOH and – optionally – some heat. If you have the salt with TFA you could dissolve your product in water add some NH3 – until you have slight alkalline conditions – and extract your product with CHCl3 or DCM, evaporate and dry over KOH.
Why is TFA used?
TFA (trifluoroacetic acid) is a commonly used mobile phase additive for reversed-phase HPLC (RP-HPLC) separations of proteins and peptides. However, TFA interferes with and significantly reduces the LC/MS signal, lowering sensitivity.
What is the deadliest acid?
Fluoroantimonic acid
| Identifiers | |
|---|---|
| Density | 2.885 g/cm3 |
| Solubility | SO2ClF, SO2 |
| Hazards | |
| Main hazards | Extremely corrosive, Violent hydrolysis |