What causes clotting factor deficiency?
Factor XII deficiency is a rare genetic blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies. It is caused by a deficiency of the factor XII (Hageman factor), a plasma protein (glycoprotein).
Which coagulation factor is not affected by vitamin deficiency?
Factor IX (also known as Christmas factor): Synthesized in the liver. Requires vitamin K to become active in coagulation. Principal factor in the intrinsic pathway of coagulation. PT (INR) not affected by deficiency of factor IX.
What is factor2 deficiency?
Prothrombin (or factor II) deficiency is a blood disorder that affects the ability of the blood to clot properly. Symptoms of the deficiency include prolonged bleeding, especially after an injury or after surgery. Women with prothrombin deficiency may have heavy menstrual bleeding.
Which conditions are associated with clotting disorders?
Major causes of coagulation disorders resulting in bleeding include:
- Hemophilia.
- Von Willebrand disease.
- Other clotting factor deficiencies.
- Disseminated intravascular coagulation.
- Liver Disease.
- Overdevelopment of circulating anticoagulants.
- Vitamin K deficiency.
- Platelet dysfunction.
Which vitamin is not required for blood clot formation?
Lack of vitamin C, which clinically is the basic defect of scurvy, does not appear to cause a defect in blood coagulation while vitamin K affects the clotting mechanism by being essential for the production of four distinct clotting factors: prothrombin, factors VII, IX and X.
What causes factor2 deficiency?
Hereditary factor II deficiency is extremely rare. It’s caused by a recessive gene, which means that both parents must carry the gene in order to pass the disease on.
How do you test for factor deficiency?
Clinical Testing and Workup Specialized tests will include screening coagulation tests that measure how long it takes the blood to clot, specifically two tests known as activated partial thromboplastin time (aPTT) and prothrombin time (PT). Individuals with factor X deficiency have both prolonged aPTT and PT.