What does it mean to have double stranded DNA antibody?

What does it mean to have double stranded DNA antibody?

Anti-(double stranded)-DNA antibodies are highly specific markers of SLE and autoimmune (lupoid) hepatitis. Raised levels are found in 50-70% of patients with active, particularly untreated, SLE. Some patients with SLE (40-60%) however, never develop anti-DNA antibodies.

What is the normal range for double stranded DNA?

Interpretation: A NORMAL result is < 10 IU/mL (NEGATIVE). An EQUIVOCAL result is 10 – 15 IU/mL. A POSITIVE result is > 15 IU/mL The results obtained by this method should serve as an aid to diagnosis and should not be interpreted as diagnostic in itself.

What diseases cause double stranded DNA?

Double Stranded DNA Antibody

  • Lupus Nephritis.
  • Lupus Vulgaris.
  • Antibody.
  • Autoantibody.
  • Double Stranded DNA.
  • Antinuclear Antibody.
  • Systemic Lupus Erythematosus.

What can cause a positive anti-dsDNA?

According to the Johns Hopkins Lupus Center, a positive anti-dsDNA result is usually associated with a severe lupus flare. A person with a low level of lupus activity may have a negative anti-dsDNA result.

Does positive dsDNA always mean lupus?

While a positive ANA test is seen in about 95% of lupus cases, it may be seen in many other conditions as well. The anti-dsDNA test is fairly specific for lupus; however, only 65-85% of people with lupus may be positive; that is, a negative anti-dsDNA does not rule out lupus.

What is considered a high level of anti-dsDNA?

Monitoring anti-dsDNA is important since levels usually vary with disease activity, high titers indicating active disease, low titers quiescent disease. Laboratories vary in how they report the test. Some do so as 0-4+ (3+ and 4+ are high), others as numbers, which vary with the test.

What is positive double stranded DNA?

A positive Double Stranded DNA Antibody Blood Test may indicate lupus in 50-70% of cases, if preceded by a positive antinuclear antibodies (ANA) blood test The laboratory test results are NOT to be interpreted as results of a “stand-alone” test.

Does double-stranded DNA mean you have lupus?

People with lupus often have an antibody in the blood called anti-double-stranded DNA, also known as anti-dsDNA. This antibody targets double-stranded DNA, the material that makes up the body’s genetic code. As lupus becomes more active, the level of anti-dsDNA autoantibodies can rise, indicating a greater risk of lupus nephritis, which can lead to kidney failure.

What are double stranded antibodies?

Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories.

What is a double stranded DNA lab test?

An autoantibody attack on the kidneys can impair kidney functioning and cause the kidneys to leak protein. This leads to a complication known as lupus nephritis. The Double Stranded DNA Antibody Blood Test is a test to detect DNA double strand antibodies.