What does mPFC stand for in brain?

What does mPFC stand for in brain?

Among the specific brain areas involved in the adult social brain, functional activity in prefrontal cortex (PFC), particularly the medial prefrontal cortex (mPFC), is of special importance for human social cognition and behavior.

What is the mPFC?

Medial prefrontal cortex (MPFC) is among those brain regions having the highest baseline metabolic activity at rest and one that exhibits decreases from this baseline across a wide variety of goal-directed behaviors in functional imaging studies.

Is OFC part of mPFC?

The two major prefrontal regions implicated in the regulation of dopamine system function are the medial prefrontal (mPFC) and orbitofrontal (OFC) cortices, regions that carry out independent, but complementary forms of cognitive processing in changing environmental conditions (Floresco et al, 2006; McAlonan and Brown.

What does the ACC do in the brain?

front-most portion of the cingulate cortex, the anterior cingulate cortex (or ACC) has been implicated in several complex cognitive functions, such as empathy, impulse control, emotion, and decision-making.

What is OFC GREY matter?

A NIDA-funded brain imaging study has shown that regular users of marijuana have less gray matter than nonusers of the drug in the orbitofrontal cortex (OFC), a brain region that contributes to impulse control, decision-making, and learning.

Is the ACC in the frontal lobe?

In the human brain, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a “collar” surrounding the frontal part of the corpus callosum.

What happens if the cingulate is damaged?

For example, someone with damage to the anterior cingulate cortex may have: Poor decision-making skills and judgment. Endocrine and autonomic dysfunction. Impaired empathy and emotional function.

What is the role of the mPFC in processing threat?

The mPFC plays an important role in processing threat and increases in activity in response to numerous psychological stressors ( Herman, 2018 ). This region, which receives extensive projections from other limbic regions, restrains activity of the HPA axis.

What is the function of the mPFC in memory?

We propose that the function of the mPFC is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses.

Which is part of the mPFC inhibits the Axis?

One subregion of the mPFC is involved in inhibiting the axis in response to psychological stressors (i.e., prelimbic cortex in rodents) while another (i.e., infralimbic in rodents) inhibits the axis in response to systemic stressors and might even play a role in enhancing responses to some psychological stressors ( Herman, 2018 ).

What kind of neurons are in the mPFC?

The mPFC, like other cortical regions, has a layered organization comprised of glutamatergic pyramidal neurons and GABAergic interneurons (Conde, Maire-Lepoivre, Audinat, & Crepel, 1995; Gabbott & Bacon, 1997; Krettek & Price, 1977).