How common is MTHFR C677T mutation?
There are two MTHFR gene variants, called C677T and A1298C, that have been an active area of study. These variants are common. In America, about 25% of people who are Hispanic, and 10-15% of people who are Caucasian have two copies of C677T.
What is the significance of having a MTHFR C677T mutation?
Recurrent miscarriages and neural tube defects are potentially associated with MTHFR. The Genetic and Rare Diseases Information Center says studies suggest that women who have two C677T variants are at an increased risk of having a child with a neural tube defect.
What does C677T mutation mean?
For MTHFR mutations, the C677T variant results in substitution of the amino acid alanine for valine. The A1298C variant results in an alanine substitution (versus a glutamine). The C677T valine substitution results in a less active form of the MTHFR enzyme.
What does heterozygous for the C677T polymorphism in the MTHFR Gene mean?
In people who are heterozygous for an MTHFR C677T mutation, there is reduced enzyme function—≈65% of normal. In people who are homozygous for MTHFR C677T, there is only 30% of normal enzyme function.
What not to eat with MTHFR?
Avoid all products with added or fortified folic acid which is the synthetic form of vitamin B9 found in fortified supplements (pregnancy supplements) breads, cereals and commercially produced flours. Avoid processed foods that have synthetic folic acid added to them.
How is MTHFR a1298c treated?
How to treat the MTHFR gene mutation? The doctor may suggest supplementation to address deficiencies, along with medications or treatments to address the specific health condition. Treatments for any disease caused by the MTFR mutation (e.g., for depression antidepressants) may be prescribed.
Can you have a healthy baby with MTHFR?
While women can get pregnant with an MTHFR gene mutation, they may have an increased risk of complications during pregnancy, including preeclampsia, congenital birth defects, and polycystic ovarian disease (PCOD).