Who NAFLD epidemiology?
Prevalence in case numbers and prevalence rates of NAFLD globally. Worldwide, the prevalence of NAFLD increased from 391.2 million in 1990 to 882.1 million in 2017, with the prevalence rate increasing from 8.2% to 10.9% during this same period (EAPC=1.05, 95% CI 1.04 to 1.07, p<0.001) (table 1; figures 1 and 2).
How many people in the world have NAFLD?
Worldwide, a systematic review of 85 studies (n = 8,515,431) estimated the pooled overall global prevalence of NAFLD diagnosed by imaging to be 25.24% [Younossi, 2016]. The highest prevalence was reported in South America and the Middle East, and the lowest rate was reported in Africa.
Why is the incidence of NAFLD on the rise worldwide?
The growing epidemic of obesity and sedentary lifestyle will continue to increase the prevalence and impact of NAFLD, making its pernicious form, NASH, potentially the most common cause of advanced liver disease and mortality in the world.
What percentage of NAFLD patients have NASH?
NAFLD is the most common chronic liver condition in the United States. It’s estimated that about 25 percent of adults in the U.S. have NAFLD. Of those with NAFLD, about 20 percent have NASH (5% of adults in the U.S.).
Is NAFLD the most common liver disease in the world?
NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease.
Can NAFLD cause cirrhosis?
The main complication of NAFLD and NASH is cirrhosis, which is late-stage scarring in the liver. Cirrhosis occurs in response to liver injury, such as the inflammation in NASH . As the liver tries to halt inflammation, it produces areas of scarring (fibrosis).
What is the life expectancy of someone with NASH?
An Australian cohort of 23 NASH cirrhotic patients found similar overall survival of 84% at 10 years. However, survival was not different when compared with patients with cirrhosis due to chronic hepatitis C, although this may have been related to a relatively small sample size.
What percentage of the population has fatty liver?
Fatty liver disease affects more than 25 percent of the U.S. population. Too much fat in the liver may cause inflammation and scarring that can predispose to cirrhosis, preventing this hardworking organ from doing its job.
What percentage of world has fatty liver?
Of 729 studies, 86 were included with a sample size of 8,515,431 from 22 countries. Global prevalence of NAFLD is 25.24% (95% CI: 22.10-28.65) with highest prevalence in the Middle East and South America and lowest in Africa.
How serious is NASH?
NASH (or nonalcoholic steatohepatitis) is a type of NAFLD that can damage the liver. NASH occurs when the fat buildup in the liver leads to inflammation (hepatitis) and scarring. NASH can be life-threatening, as it can cause liver scarring (called cirrhosis) or liver cancer.
What is the life expectancy of someone with Nash?