How do bisphosphonates work in osteogenesis imperfecta?

Osteogenesis imperfecta is caused by a genetic defect resulting in an abnormal type I collagen bone matrix which typically results in multiple fractures with little or no trauma. Bisphosphonates are used in an attempt to increase bone mineral density and reduce these fractures in people with osteogenesis imperfecta.

Can bisphosphonates cause avascular necrosis?

[5] Without resorption and new bone formation, old bone survives beyond its lifespan, and its capillary network is not maintained, leading to avascular necrosis of the jaw. Also, high potency biphosphonates can lead to necrosis by the toxicity of soft tissue and bone cells, further complicated by infection.

How does bisphosphonates treat osteoporosis?

Bisphosphonates slow bone resorption by reducing osteoclast function. Many studies have shown that this class of medication can improve bone density and reduce the risk of fracture in patients with a reduced bone density.

Is avascular necrosis related to osteoporosis?

While osteoporosis and aging are common risk factors for Kummel disease, other cases of AVN may be caused by different non-traumatic factors.

What are the types of osteogenesis imperfecta?

Type I: This is the mildest and most common form of OI. Type I leads to broken bones (bone fractures) or muscle weakness.
Type II: Babies born with Type II often can’t breathe and die young.
Type III: Babies often have broken bones at birth.
Type IV: Bones may break easily.

How often is pamidronate given?

It may be given once every 3 to 4 weeks, once a day for 3 days in a row, or as a single dose that may be repeated after 1 week or longer. The treatment schedule depends on your condition.

What kind of doctor treats osteonecrosis of the jaw?

Treatment of ONJ Once established, osteonecrosis of the jaw is challenging to treat and should be managed by an oral surgeon with experience treating ONJ. Treatment of ONJ typically involves limited debridement, antibiotics, and antibacterial oral rinses (eg, chlorhexidine; 1. It may cause pain or may be asymptomatic.

Why bisphosphonates is the drug of choice for osteoporosis?

Bisphosphonate therapy normalizes bone turnover, reduces the number of bone remodeling sites and stress risers, restores the balance of bone remodeling, prevents bone loss and deterioration of bone structure and, in patients with osteoporosis, reduces fracture risk (5).