What is oxidative stress in kidney?
Oxidative stress is increased in patients with renal impairment as a result of increased oxidant activity and reduced antioxidant capacity, and this is increased in a graded manner with increasing renal dysfunction. Inflammation, which is also present in CKD, further amplifies the oxidant generation process.
Why does GFR decrease in diabetic nephropathy?
Since the glucose levels were lowered, the kidney’s function of filtering materials goes back to the normal rate. Results from this study are similar to the findings by Rudy 2003 and Mongensen 2004 who found that glycaemic control reduces hyperfiltration and hence having an effect of lowering the GFR.
Can type 2 diabetes cause oxidative stress?
Chronic hyperglycaemia is seen as a principal factor in promoting the development of micro-vascular and macro-vascular complications in type 2 diabetes and hyperglycaemia is known to be responsible for the damage of DNA, lipids and proteins and the degree of damage has been linked to the degree of hyperglycaemic- …
Does oxidative stress affect the kidneys?
Conclusion. Oxidative stress damages renal tissue and promotes inflammation leading to further tissue injury with accumulation of impaired biomacromolecules. These can be measured also in saliva and urine which are easily collectible.
Can diabetic nephropathy be cured?
There is no cure for diabetic nephropathy, but treatments can delay or stop the progression of the disease. Treatments consist of keeping blood sugar levels under control and blood pressure levels within their target range through medications and lifestyle changes.
Can you reverse diabetic nephropathy?
These studies demonstrate that diabetic nephropathy can be reversed by a relatively simple dietary intervention. Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined.
What is oxidative damage in the body?
Oxidative stress is a state that occurs when there is an excess of free radicals in the body’s cells. The body produces free radicals during normal metabolic processes. Oxidative stress can damage cells, proteins, and DNA, which can contribute to aging.