Is bromodomain a DNA binding motif?

Is bromodomain a DNA binding motif?

We show that bromodomain-mediated DNA binding is conserved among members of the BET family, indicating that bivalent nucleosome recognition through simultaneous DNA and histone tail binding is an important component of nucleosome recognition by BET bromodomains and possibly in bromodomains beyond the BET family.

Where are Bromodomains located?

Histone lysine acetylation is central to epigenetic control of gene transcription. The bromodomain, found in chromatin-associated proteins and histone acetyltranferases, functions as the sole protein module known to bind acetyl-lysine motifs.

Does BRG1 bind to DNA?

BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure regulation. Surprisingly, we also find that both BRG1 and hBRM BRDs have DNA-binding activity.