Do bisphosphonates prevent fractures?
Results. The use of bisphosphonate decrease the risk of overall osteoporotic fracture (odds ratio [OR] 0.62; P<0.001), vertebral fracture (OR 0.55; P<0.001) and non-vertebral fracture (OR 0.73; P<0.001).
How do bisphosphonates affect bone healing?
In animal studies, BPs have been shown to cause low bone turnover (18). Other studies have shown that bisphosphonate can promote fracture healing in vivo and in vitro (14, 19), accelerating the formation of trabecular bone and the thickness of cortical bone callus (20).
Why do bisphosphonates cause fractures?
Long-term bisphosphonate therapy can change bones at the microscopic level to make them more susceptible to the rare catastrophic transverse breaks known as atypical femoral fractures (AFFs), scientists said.
What conditions are bisphosphonates used for?
Bisphosphonates are primary agents in the current pharmacological arsenal against osteoclast-mediated bone loss due to osteoporosis, Paget disease of bone, malignancies metastatic to bone, multiple myeloma, and hypercalcemia of malignancy.
When do you start bisphosphonates after a fracture?
It has been suggested that the early use of bisphosphonates during or after the first two weeks following surgical intervention may reduce fracture and mortality rates by increasing bone mineral density (BMD), therefore a decrease in the incidence of secondary fracture can be expected by administering bisphosphonates …
Can Fosamax cause brittle bones?
In rare cases, people who take the drug may suffer from serious side effects such as femur fractures, jaw problems and esophageal ulcers. For many people, one of the worries that comes with getting older is the risk of developing osteoporosis. This debilitating disease makes bones so brittle they easily break.
Do bisphosphonates cause brittle bones?
Bisphosphonates Cause Brittle, Aged Bone With More Mineralization. The researchers first established that biopsies taken from patients who had developed an AFF showed evidence of elevated tissue mineralization.