What is the Rf value for acetaminophen?
The solvent system was found to give compact spot for chlorzoxazone (Rf values of 0.23 ± 0.021), diclofenac sodium (Rf values of 0.51 ± 0.035) and paracetamol (Rf values of 0.64 ± 0.028).
What are 3 factors that can affect Rf values in TLC?
Rf values and reproducibility can be affected by a number of different factors such as layer thickness, moisture on the TLC plate, vessel saturation, temperature, depth of mobile phase, nature of the TLC plate, sample size, and solvent parameters. These effects normally cause an increase in Rf values.
What is a good Rf value for TLC?
between 0.3 and 0.7
The best Rf (retention or retardation factor) lies between 0.3 and 0.7. If you want the Rf of your TLC spot to be smaller, i.e., the spot to be lower down on the plate, you must decrease the eluent polarity.
What is the Rf of aspirin acetaminophen and caffeine which one has the highest polarity?
Aspirin has the third highest R F value with two dipole-dipole forces and one hydrogen bond, almost identical to the R F value of Phenacetin. Acetaminophen has two hydrogen bonds and one dipole-dipole making it more polar than Aspirin, Phenacetin, and Ibuprofen.
What is the Rf value of 4 aminophenol?
The Rf values were 0.18, 0.34, 0.69 and 0.76 for PAR, 4-AP, LOR and PSH, respectively.
What is TLC principle?
What is the principle of TLC? TCL is based on the principle of separation through adsorption type. The separation relies on the relative empathy of compounds towards the mobile phase and stationary phase.
What factors affect Rf values in TLC?
Retention Factor Rf values and reproducibility can be affected by a number of different factors such as layer thickness, moisture on the TLC plate, vessel saturation, temperature, depth of mobile phase, nature of the TLC plate, sample size, and solvent parameters. These effects normally cause an increase in Rf values.
Which is more polar acetylsalicylic acid or acetaminophen?
Acetaminophen has two hydrogen bonds and one dipole-dipole making it more polar than Aspirin, Phenacetin, and Ibuprofen.
How can I get 4-aminophenol?
It is produced from phenol by nitration followed by reduction with iron. Alternatively, the partial hydrogenation of nitrobenzene affords phenylhydroxylamine, which rearranges primarily to 4-aminophenol: C6H5NO2 + 2 H2 → C6H5NHOH + H2O.