What should be avoided when taking ticlopidine hydrochloride?
You should not take ticlopidine if you have any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury), or a blood cell disorder such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).
What drugs interact with clopidogrel?
Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to competitively inhibit CYP activation of clopidogrel, reducing clopidogrel responsiveness. Conversely, other agents increase clopidogrel responsiveness by inducing CYP activity.
When should I take Ticlid?
How to use Ticlopidine 250 Mg Tablet
- Read the Patient Information Leaflet if available from your pharmacist before you start taking ticlopidine and each time you get a refill.
- Take this medication by mouth with food or just after a meal as directed by your doctor, usually twice daily.
Why was ticlopidine discontinued?
Ticlopidine was approved for use in the United States in 1991, but it is currently rarely used, largely because of the risks of serious side effects including agranulocytosis, thrombotic thrombocytopenic purpura and aplastic anemia and the availability of clopidogrel, which has a similar mechanism of action and …
Is ticlid reversible?
Ticlopidine hydrochloride binds reversibly (98%) to plasma proteins, mainly to serum albumin and lipoproteins. The binding to albumin and lipoproteins is nonsaturable over a wide concentration range.
Why was ticlid discontinued?
How long should I stay on clopidogrel?
The standard recommendation is typically at least 12 months of Plavix. But the study found that six months of treatment was enough to prevent rare but deadly complications, says researcher Marco Valgimigli, MD, of the University Hospital of Ferrara, in Italy.
What is the antidote for ticlopidine?
Prolonged bleeding time is normalized within 2 hours after administration of 20 mg methylprednisolone IV. Platelet transfusions may also be used to reverse the effect of TICLID (ticlopidine hcl) on bleeding.