What is the adverse effect of zileuton?
This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed and have problems with sleep. If you or your caregiver notice any of these side effects, tell your doctor right away.
What is zileuton used for?
Zileuton is used to prevent wheezing, shortness of breath, coughing, and chest tightness due to asthma. Zileuton is not used to treat an asthma attack (sudden episode of shortness of breath, wheezing, and coughing) that has already started.
How do zileuton help treat asthma?
BRAND NAME(S): Zyflo. USES: This medication is used to control long-term (chronic) asthma and help decrease the number of asthma attacks. Controlling asthma can decrease time lost from work or school. This drug improves asthma symptoms by blocking substances in the body called leukotrienes.
What is the pharmacokinetics of zileuton?
Zileuton is rapidly absorbed upon oral administration with a mean time to peak plasma concentration (Tmax) of 1.7 hours and a mean peak level (Cmax) of 4.98 μg/mL. The absolute bioavailability of ZYFLO is unknown. Systemic exposure (mean AUC) following 600 mg ZYFLO administration is 19.2 μg.
What is the most common side effect of Accolate?
Common side effects may include: nausea, diarrhea, stomach pain; headache; or. cold symptoms such as stuffy nose, sneezing, sore throat.
Is zileuton a controlled substance?
Zileuton is used in the treatment of asthma, maintenance and belongs to the drug class leukotriene modifiers. Risk cannot be ruled out during pregnancy. Zileuton 600 mg is not a controlled substance under the Controlled Substances Act (CSA).
Why was zafirlukast discontinued?
Commercial reasons are cited for this decision and it is stressed that there were no safety concerns with this medicine. Zafirlukast is a leukotriene receptor antagonist and as such the closest available alternative is montelukast. Action: Clinicians should be aware of this product being discontinued.
Does zafirlukast cause weight gain?
Weight gain is not a common side effect of zafirlukast (Accolate). Sometimes, people might have stomach issues, like diarrhea or nausea, when they start this medication, but they typically don’t gain weight.
How does zileuton work in patients with hepatic impairment?
The mean apparent plasma clearance of zileuton in subjects with hepatic impairment was approximately half the value of the healthy subjects. The percent binding of zileuton to plasma proteins after multiple dosing was significantly reduced in patients with moderate hepatic impairment.
How to report side effects of zileuton in Canada?
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking zileuton, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
How is the metabolite of zileuton metabolized?
Hepatic and gastrointestinal; zileuton and N-dehydroxylated metabolite can be metabolized via CYP1A2, 2C9, and 3A4 The mean apparent plasma clearance of zileuton in subjects with hepatic impairment was approximately half the value of the healthy subjects.
How often should you take a zileuton tablet?
Zileuton tablets and extended-release tablets contain the same amount of the drug, but they are not taken in the same way. Follow your doctor’s instructions. Zileuton tablets are usually taken 4 times daily, with meals and at bedtime. Zileuton tablets may be swallowed whole or split in half to make swallowing easier.