Is lamotrigine safe in pregnancy?

Is lamotrigine safe in pregnancy?

Given its favorable reproductive safety profile, lamotrigine is a reasonable option for women who require treatment with a mood stabilizer during pregnancy.

Can you take carbamazepine while pregnant?

Answer: Similar to valproic acid, carbamazepine increases the risk of neural tube defects; however, it does not increase the risk of other malformations. Carbamazepine is also not associated with an increased risk of developmental delay.

What anti epileptics are safe in pregnancy?

A review of the risks of major congenital malformations and of adverse neurodevelopmental outcomes for antiepileptic drugs by the Commission on Human Medicines has confirmed that lamotrigine (Lamictal) and levetiracetam (Keppra) are the safer of the medicines reviewed during pregnancy.

Is levetiracetam safe during pregnancy?

Levetiracetam (LEV) is one such AED which is supposed to be effective in controlling seizures during pregnancy and relatively free of teratogenic side effects.

What birth defects can lamotrigine cause?

A study published last year in the journal Neurology also found that babies born to pregnant women taking lamotrigine appeared not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot.

Does lamotrigine cross the placenta?

Lamotrigine has a good tolerability and safety profile, but is known to cross the placenta. There is no consensus regarding its use in pregnancy.

Can carbamazepine cause birth defects?

Along with valproic acid, carbamazepine might increase the risk for spina bifida (a major birth defect of the baby’s spine) and cleft palate (a birth defect of the baby’s mouth).

Can carbamazepine cause miscarriage?

A few studies have observed slightly more miscarriages among women taking carbamazepine or other antiepileptic medications during pregnancy, while other studies have not. The women’s underlying health conditions might have been responsible for the increased incidence of miscarriage in the studies.

How do you manage epilepsy during pregnancy?

Women with epilepsy (WWE) are advised to continue antiepileptic drugs (AEDs) during pregnancy to reduce maternal and fetal trauma associated with seizures. The goal is optimal seizure control with minimum fetal exposure to AEDs.

Can levetiracetam cause birth defects?

Recent studies carried out by the Commission on Human Medicines (CHM), looking at the risks associated with commonly prescribed AEDs shows that lamotrigine (Lamictal) and levetiracetam (Keppra) are safer to use during pregnancy than other AEDs, having low rates of physical birth abnormalities, in line with the …

How much Keppra is safe during pregnancy?

The mean daily dose of levetiracetam was 3,000 mg for cases with major malformations, 1,148 mg for cases of minor malformations, and 1,680 mg for those with no malformations.